Basic Information
VIS ID
TVIS10013804
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1894
Orient
+
Integrated sequence
ATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGC| |TTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCT
Host Sequence
Chromosome
chr8
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
47541849/46630227 (Hg38)
End
47541849/46630227 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/3733952; hsa-mir-10400/Downstream/15084561;
Nearest TSS
ENST00000518652/Upstream/3434059; ENST00000518278/Downstream/192010;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/12475, chr8-CpG: 32/Downstream/324520
Nearby gene
LINC00293(+210659) ;
Upstream sequence
ggggtttcactgtgttagccaggatggtctcgatctcctgacctcgtgatccacccgccttggcctcccaaagtgctgggattacaggcgtgagccgtcg
Downstream sequence
gttagggaggattccctctttttctattgattggaatagtttcagaaggaatggtaccagctcctccttgtacctctggtagaattcggctgtgaatcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate