Basic Information
VIS ID
TVIS10013811
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
88375179/85760264 (Hg38)
End
88375179/85760264 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC100419824 ; LOC102724057
Nearest miRNA
hsa-mir-101-2/Upstream/1790407; hsa-let-7a-1/Downstream/2985572;
Nearest TSS
ENST00000422679/Upstream/18235; ENST00000416045/Downstream/4848;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/17814, chr9-CpG: 127/Downstream/44807
Nearby gene
LOC389765(+45738) ;
Upstream sequence
TCATGATAATTTCAAGTGTGTTTTGATTTGAGAATTTCTTTATGAAAGTCTTCAAAAATCCCACCTCTTAATCCATGGAATTTTCCCTGGAGTCTGAAAA
Downstream sequence
tttatgaggccagcatcatcctgataccaaagcctggcagagacacaacaaaaaaagagaattttagaccaatatccttgatgaacatcgatgcaaaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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