Basic Information
VIS ID
TVIS10013826
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1767
Orient
-
Integrated sequence
TTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGT| |CTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTC
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
153421459/153448983 (Hg38)
End
153421459/153448983 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/1903092; hsa-mir-1182/Downstream/240722;
Nearest TSS
ENST00000473358/Upstream/9034; ENST00000420695/Downstream/10891;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/187146, chr1-CpG: 40/Downstream/86965
Nearby gene
S100A7L2(-8956) ; S100A7(+8761) ;
Nearest cancer related gene
S100A7(OG, +8761) ;
Upstream sequence
ccaaaagtgttgggattacaggcatgagccacagcacccggccaaggctttttaaatgtgcagcttcactctcaatttcttctttttctcctttcatttt
Downstream sequence
gttgttgttgttgtagaaagtgggttatttttcctgcagaatttcctacagactggagttcctgattgcatccatgtggtgtcaattaacagattactca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate