Basic Information
VIS ID
TVIS10013828
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2453
Orient
-
Integrated sequence
GACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTA| |GTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATAT
Host Sequence
Chromosome
chr1
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
166688612/166719375 (Hg38)
End
166688612/166719375 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/564577; hsa-mir-1182/Downstream/1279285;
Nearest TSS
ENST00000473358/Upstream/229336; ENST00000449930/Downstream/120072;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/552164, chr1-CpG: 112/Downstream/119729
Nearby gene
FMO9P(-94139) ; POGK(+120112) ;
Upstream sequence
gtgacagttcgggacttctggcttcttatggtttcgctaaagttttaggttactaaggatcagaattctagttaataggtaattctgtatacaaaatgtg
Downstream sequence
tcagaaagtgttgtgttattagtgagaaaaagaatacttttgcctaactgagtagttatctaaaagttagttcaaattacagatttgaaaaggttatttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate