Basic Information
VIS ID
TVIS10013831
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1708
Orient
-
Integrated sequence
CATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATAC| |TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
194919217/194950087 (Hg38)
End
194919217/194950087 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/1813504; hsa-mir-1182/Downstream/1632326;
Nearest TSS
ENST00000473358/Upstream/599144; ENST00000496761/Downstream/1110986;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1827993, chr1-CpG: 24/Downstream/1658491
Nearby gene
CDC73(-1695275) ; KCNT2(+1275696) ;
Nearest cancer related gene
CDC73(TSG, -1695275) ;
Upstream sequence
ttaaatgcctatattaaaaaagataggaatatcttaagtgaacaacctaatgtcatatctgaaggaactagaatatcaagaataatccaaaccctaagct
Downstream sequence
agccgaagaaaataacaaagaggggaggagaactaaatgagagtgagatgacaaaatgcatgcgaagcatcgatgaaacaaaaagttggttcctagaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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