Basic Information
VIS ID
TVIS10013832
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1922
Orient
+
Integrated sequence
TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA| |AGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAA
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
194919218/194950088 (Hg38)
End
194919218/194950088 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/1813505; hsa-mir-1182/Downstream/1632325;
Nearest TSS
ENST00000473358/Upstream/599145; ENST00000496761/Downstream/1110985;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1827994, chr1-CpG: 24/Downstream/1658490
Nearby gene
CDC73(-1695276) ; KCNT2(+1275695) ;
Nearest cancer related gene
CDC73(TSG, -1695276) ;
Upstream sequence
taaatgcctatattaaaaaagataggaatatcttaagtgaacaacctaatgtcatatctgaaggaactagaatatcaagaataatccaaaccctaagcta
Downstream sequence
gccgaagaaaataacaaagaggggaggagaactaaatgagagtgagatgacaaaatgcatgcgaagcatcgatgaaacaaaaagttggttcctagaaagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate