Basic Information
VIS ID
TVIS10013838
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1851
Orient
+
Integrated sequence
AGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGT| |TCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCT
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
60726342/60260670 (Hg38)
End
60726342/60260670 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
LOC105378761 ; LOC107984962
Nearest miRNA
hsa-mir-12136/Upstream/527374; hsa-mir-101-1/Downstream/1585405;
Nearest TSS
ENST00000473358/Upstream/145795; ENST00000496712/Downstream/335536;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/186802, chr1-CpG: 86/Downstream/782300
Nearby gene
C1orf87(-186900) ; NFIA(+816604) ;
Upstream sequence
AGGGACTGGATAGGATTCCTTTAACTGGGAAGCAGAAAAAGCAACTTTCATCAGGGGCCAGGGAGCAAATGGTAGAAACACAGAACAAGCTACAACACAG
Downstream sequence
AACAAACACAGAACAACCTTGAGTGTGGACACCACATCAGATGAATAACCTGCCCATTGACATTACTAGGCATGGTTAGCACCAGTCAACATGAATTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate