Basic Information
VIS ID
TVIS10013848
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2307
Orient
+
Integrated sequence
GTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCA| |AATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTC
Host Sequence
Chromosome
chr11
Cytoband
p11.12
Reference genome
GRCh37/hg19
Start
49438692/49417140 (Hg38)
End
49438692/49417140 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-129-2/Upstream/1320282; hsa-let-7a-2/Downstream/7326733;
Nearest TSS
ENST00000527297/Upstream/208470; ENST00000555099/Downstream/535251;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/208652, chr11-CpG: 37/Downstream/141240
Nearby gene
FOLH1(-208470) ; LOC440040(+141388) ;
Upstream sequence
TAGCTGTACATTTTAAGCTAGCAGGTCAAAGGTTGGTACATGGTAGAAAAGGTGGTATTGAAAAAGAAGTGATAAGGCTTCAAACAAAATGAATACAATT
Downstream sequence
TTAGAAAACCATTTTCAACATTTTGAAGCACAATAACGAAGAGAACAAGGAAGCCAAGTGGAAGAAATGGTGTTGATTTTTTCCATGACAGAAAACAATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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