Basic Information
VIS ID
TVIS10013851
Fusion event
HBV-LOC105370003 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1698
Orient
-
Integrated sequence
CTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCT| |TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
116189500/115751695 (Hg38)
End
116189500/115751695 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
LOC105370003
Nearest miRNA
hsa-let-7i/Upstream/2460087; hsa-mir-1178/Downstream/396865;
Nearest TSS
ENST00000382841/Upstream/111961; ENST00000549163/Downstream/3567;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/299505, chr12-CpG: 46/Downstream/165287
Nearby gene
TBX3(-1067531) ; MED13L(+206881) ;
Upstream sequence
ctccagcctgggtgacaaagtgagactgtcttaaaagaaaaagaaTTGTTGGCTTCTCTCAGCCTCCACCCAAATGGCATCTCCTTAGGACAGTAAGTTT
Downstream sequence
TCACTTCCCATTTCTCAATACCTCAAATATCTCTCTCCCCTGGGACATTGCTCCAGGAAAGGTCAAGGGGACTTTTGGTTCAATGGATTTTCTTCATTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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