Basic Information
VIS ID
TVIS10013859
Fusion event
HBV-LOC107984526 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2078
Orient
+
Integrated sequence
CAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAAT| |TCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAAT
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
68269344/67875564 (Hg38)
End
68269344/67875564 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107984526
Nearest miRNA
hsa-let-7i/Upstream/1624407; hsa-mir-1178/Downstream/1397593;
Nearest TSS
ENST00000382841/Upstream/146089; ENST00000545520/Downstream/53671;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/225468, chr12-CpG: 54/Downstream/456503
Nearby gene
DYRK2(-212900) ; IFNG(+279206) ;
Upstream sequence
GAAGTAACTTGAATTTACACGTTTGGGATGAATAATAAGCAGCAGCATATATATGCATTATATTGTTTGACCATCATAAAAGCCTAATAGGTGTCCGTCT
Downstream sequence
GGCCGAGCTTTATAATTCTACTGGattatttatttaaaaaaattaaGAAAGGCCTCACTCAAAttattcaattaaacatatttattgcatgcttactctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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