Basic Information
VIS ID
TVIS10013864
Fusion event
HBV-LOC105370312 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
91770992/91118738 (Hg38)
End
91770992/91118738 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370312
Nearest miRNA
hsa-mir-1297/Upstream/887461; hsa-mir-1267/Downstream/231867;
Nearest TSS
ENST00000623511/Upstream/29145; ENST00000618596/Downstream/12627;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1755217, chr13-CpG: 49/Downstream/56257
Nearby gene
LINC00410(-192141) ; LINC00379(+8875) ;
Upstream sequence
AGTAATAATCAAAAAGGAAAGTTAAGTTTAAAAAAAGATGAAAACTGTAGAATGCAAGGCTTTCTGTCATTAAAAGTCACTTTTACCAAAATATAGATTT
Downstream sequence
ATCAGATTTAATCATAATGTTAGTGTACATAATAAAAACTATCAAAGAGGCCAAAATTTTTATTCACCATCTGAGTGAATAAAAGTATGAAAGTAATTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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