Basic Information
VIS ID
TVIS10013868
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1839
Orient
+
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA| |ATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTG
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
87643643/87177299 (Hg38)
End
87643643/87177299 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/9911009; hsa-mir-1185-1/Downstream/6770927;
Nearest TSS
ENST00000550708/Upstream/240659; ENST00000555490/Downstream/73804;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1643165, chr14-CpG: 87/Downstream/815253
Nearby gene
LINC01148(-254544) ; GALC(+755715) ;
Upstream sequence
AGAGAGGGAAGATGCCCAGGGACTGGCTATGGATGCACCCTCATTTGCCTGTATCTAAGGTTTTCACCAAAACTGTAGGAATGAGGTGTCCATTGtgata
Downstream sequence
tagtttggatctgtattcccacccaaatctcatgttgaaatgtaattcccagtactggaggtggggactggtgggaggtgattggatcatggggggatgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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