DENND4A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013869
Fusion event
HBV-DENND4A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2513
Orient
+
Integrated sequence
CGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTG| |TCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAA
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
66083077/65790739 (Hg38)
End
66083077/65790739 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
DENND4A
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-10393/Upstream/71407; hsa-mir-11181/Downstream/249494;
Nearest TSS
ENST00000557528/Upstream/29302; ENST00000563580/Downstream/1385;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/179407, chr15-CpG: 104/Downstream/762
Upstream sequence
AAGTAAAAATTGCCGAAAATGTTTAATTCTGCCCAAAACAGTTTCCAAAAAAGAAGCCaaatataatattttattttaaGTTCAAACAGGGTTCAAACAG
Downstream sequence
CTCAGAAATTTTGTATACTTAAGTTTTCAGAAGTCGAATCCCAGAACCGCTATCAACATAAACTGAATAACTTGCTCAAGAGTCCTTACTTATTACCCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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