Basic Information
VIS ID
TVIS10013877
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2144
Orient
+
Integrated sequence
GTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTC| |TAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACA
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
26634554/26623233 (Hg38)
End
26634554/26623233 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA16E
Nearest miRNA
hsa-mir-1225/Upstream/597923; hsa-mir-11401/Downstream/1767749;
Nearest TSS
ENST00000527434/Upstream/28420; ENST00000562900/Downstream/98641;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/929923, chr16-CpG: 34/Downstream/486457
Nearby gene
HS3ST4(-485545) ; C16orf82(+443665) ;
Upstream sequence
atttactgagcagctactactttccaggcatcgttctgggaactTTTTGTGCATGACTTAATGGAATTCTCATTTAGAAAAAGAAAACCCTGGCCAGGAA
Downstream sequence
ATgtggctcacacctgtaattccaacactttgggaggccaaggtgggaagatctcttgagcccaagagttcaagaccagtctgggcaacacagcaagtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate