Basic Information
VIS ID
TVIS10013880
Fusion event
HBV-CLUHP3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1791
Orient
-
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2601723/2698429 (Hg38)
End
2601723/2698429 (Hg38)
Orient
-
Location type
Exonic
Target gene
CLUHP3
Nearest miRNA
hsa-mir-132/Upstream/5510; hsa-mir-10226/Downstream/49649;
Nearest TSS
ENST00000595228/Upstream/1956; ENST00000572876/Downstream/3021;
Nearest CpG islands
chr17-CpG: 89/Target, None/Upstream, None/Downstream
Upstream sequence
GCCCAGCGTGTACAGCCCCTCCACGTCCACCGCGTTGTACGTGCGGACGCCATTCAGGTCGTTGGTGGGCGCCACGTAGGCCGCCACGTCCCCCCCGAAG
Downstream sequence
TCCTTGTAGTGGTCTCGGACGTCGAAGCCCAGGCTGAAGAAGATGTTGTTCCAGATGAACATCTGCATCTTGGTCTCCTCGCTGGGGTTGATGGCCATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate