Basic Information
VIS ID
TVIS10013882
Fusion event
HBV-ROCK1P1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
108361/108361 (Hg38)
End
108361/108361 (Hg38)
Orient
-
Location type
upstream
Target gene
ROCK1P1
Nearest miRNA
hsa-mir-1-2/Downstream/3895;
Nearest TSS
ENST00000575820/Upstream/34816; ENST00000580410/Downstream/50022;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/32334, chr18-CpG: 21/Downstream/3948
Upstream sequence
gacattgtgacatatctctgcactgatctcccaggtgctgtaacttttgtctaggctctggctacacagcattgtgacatatgactgcactgatcaccca
Downstream sequence
ggtgatataactcttgtctaggctctgcctacagggggcttgtgacatatctctgcactgatcacccaggtgatataactcttctctaggatctgcctac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate