VISDB Viral Integration Site DataBase

VIS ID

TVIS10013883

Fusion event

HBV-CCBE1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2029

Orient

+

Integrated sequence

GGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAG| |AGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTT

Chromosome

chr18

Cytoband

q21.32

Reference genome

Start

End

57309186/59641954 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-4443 ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-3613-3p ; hsa-mir-6807-5p ; hsa-mir-3940-3p ; hsa-mir-4279 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-1207-3p ; hsa-mir-646 ; hsa-mir-122-3p ; hsa-mir-552-5p ; hsa-mir-2355-3p ; hsa-mir-4646-3p ; hsa-mir-676-3p ; hsa-mir-6852-3p ; hsa-mir-4286 ; hsa-mir-3909 ; hsa-mir-6749-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1208 ; hsa-mir-6760-3p ; hsa-mir-548j-3p ; hsa-mir-548x-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6875-3p ; hsa-mir-6883-3p ; hsa-mir-4778-3p ; hsa-mir-5009-3p ; hsa-mir-3121-3p ; hsa-mir-6881-3p ; hsa-mir-6873-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4326 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-4277 ; hsa-mir-584-3p ; hsa-mir-330-3p ; hsa-mir-4524a-3p

Nearest miRNA

hsa-mir-1-2/Upstream/1190796; hsa-mir-5011/Downstream/7439630;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/282417, chr18-CpG: 119/Downstream/54528

Upstream sequence

agcattaatatcggagaggcttggaccctgccttcccataaggggaagaaaacgcagctggattcctgtctcatactttacataaaaaaattctacatgg

Downstream sequence

attggagaaggtgaaactacaaaactttaggagagaatgcaggtagatattgagaaaaaatgtataaaccatgaaggaaaaagggtgataaaatcgatga