Basic Information
VIS ID
TVIS10013885
Fusion event
HBV-LOC105376872 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr18
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
68157511/70490275 (Hg38)
End
68157511/70490275 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105376872
Nearest miRNA
hsa-mir-1-2/Upstream/3408589; hsa-mir-548av/Downstream/2363046;
Nearest TSS
ENST00000575820/Upstream/105684; ENST00000563639/Downstream/160469;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/59415, chr18-CpG: 225/Downstream/2051464
Nearby gene
SOCS6(-160077) ; LINC01541(+1029689) ;
Upstream sequence
TGAAAGATTGCAGCAGAACTGGGAAGTGAAAGCACGGAGAGGCTGTGGGACATGGAGGAGGGGCGGTAAGATTGAGAAAGAGGTAACAGTTGGGGTGACT
Downstream sequence
TTGGACCTGAGACCTGGGCAGGCATAAGAAGTCTCACTCTCTATTCCATTCTTGGCAGGGGATGTTTCTTTGTACCAGGTAGCTTTGCGCTTGTTTTGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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