ZNF407 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013887
Fusion event
HBV-ZNF407 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2424
Orient
+
Integrated sequence
AACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGA| |AGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCT
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
72516858/74804902 (Hg38)
End
72516858/74804902 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF407
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1-2/Upstream/1951520;
Nearest TSS
ENST00000575820/Upstream/173882; ENST00000581829/Downstream/72296;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/206174, chr18-CpG: 23/Downstream/282785
Upstream sequence
ATTTAAAGTAACACTAAGCATGTGCTTGCTTTCTGAATATTATCCTCCTCCACCTCCTTCCAACCACCCTGCCGAGGATCTGGCTGTGACAGTTTGATTA
Downstream sequence
GATCATCAATCCTCACTGTTAACAGCACTTTTCCTGAACACCTGGGCTGCCAGGTCACATCTGAATTCAGCTACCGTTGTTTCAGTGACCCGACGTGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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