VISDB Viral Integration Site DataBase

VIS ID

TVIS10013893

Fusion event

HBV-LRP1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1829

Orient

+

Integrated sequence

GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT

Chromosome

chr2

Cytoband

q22.2

Reference genome

Start

End

142582581/141825012 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a

Nearest miRNA

hsa-mir-128-1/Upstream/1238327; hsa-mir-10b/Downstream/7505266;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/3043932, chr2-CpG: 58/Downstream/305143

Nearest cancer related gene

LRP1B(TSG, No orient, 0)

Upstream sequence

ttccctcttgctgttctctagatagtgagggagttctcacaagatccgatggtttttaaagtggtagtttaccctgtgcggtctctctcctgccaccttg

Downstream sequence

tgaagaaggtattttcttcccctttgccttttgccatgattttaagtttcctgaggccgccccaaacatgcggaactgtgagtcaattaaagctcttttg