Basic Information
VIS ID
TVIS10013900
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
+
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
70533038/70305906 (Hg38)
End
70533038/70305906 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2E
Nearest miRNA
hsa-mir-1285-2/Upstream/52901; hsa-mir-10b/Downstream/4784906;
Nearest TSS
ENST00000437798/Upstream/3816; ENST00000452525/Downstream/97028;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3701, chr2-CpG: 136/Downstream/247011
Nearby gene
FAM136A(-3818) ; TGFA(+141374) ;
Upstream sequence
GCACAAGAGGGACTAGGGCTCTTTCCTATTTTCTCATGTTCAGGATGTGGGTGAGATAAATGGGGGCCAGGAGGCCCGGGATGAGGGGAGGAAGTGAATT
Downstream sequence
TTGCTAGATGCTGCTACCTTTTCTAACCCTCAGGTTAGCAATGGGTGGTAGCCAGAAACCCAGCTATGGCCAACCTTGGTTAAAGACTTCCAGATGAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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