Basic Information
VIS ID
TVIS10013909
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1835
Orient
+
Integrated sequence
GAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTG| |CCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCT
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
16042445/16000938 (Hg38)
End
16042445/16000938 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/127089; hsa-let-7g/Downstream/932258;
Nearest TSS
ENST00000440867/Upstream/141167; ENST00000470031/Downstream/173711;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/140455, chr3-CpG: 69/Downstream/263691
Nearby gene
MIR563(-127089) ; GALNT15(+173739) ;
Upstream sequence
AAAAATCTTTCACGTTGCTTCATTGTCCCTAAACAAAGTTCAGACGTGCTAGACTGCATTGTGAGGTCCTTCTCACCCTGGTATTACCTGGCTTTCAATC
Downstream sequence
ctagcttctggaagtttgttggcaatctttggtgttccttggtttatagatgcatgacccagatctctgcctttatgttcccatggtgctctcccagtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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