Basic Information
VIS ID
TVIS10013911
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1619
Orient
-
Integrated sequence
CACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCA| |CCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTG
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
195683409/195956538 (Hg38)
End
195683409/195956538 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/74143; hsa-mir-4797/Downstream/1337340;
Nearest TSS
ENST00000440867/Upstream/44444; ENST00000457079/Downstream/98676;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1846, chr3-CpG: 127/Downstream/33107
Nearby gene
TNK2(-47529) ; SDHAP1(+3383) ;
Upstream sequence
GCAGATGGCACTGACAGTCCCAAGAATAGTCAAGAACTATTCTGTTCTTGCAGAAAGCTGCTTTTAAACATAGTCCAGAGAACTTGATTTAATCTTATCA
Downstream sequence
ATGTCAGCCGTGGAGGTTTTCAAACTGTGGTCcctggacatgttagaaatgcaaattctcaggccgaaccaggactgaataggaagatctggggtagggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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