VISDB Viral Integration Site DataBase

VIS ID

TVIS10013912

Fusion event

HBV-ZNF385D integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1820

Orient

-

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr3

Cytoband

p24.3

Reference genome

Start

End

22311553/22270062 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-6734-3p ; hsa-mir-3667-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-5088-3p

Nearest miRNA

hsa-mir-12127/Upstream/2132421; hsa-let-7g/Downstream/3394811;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/2083598, chr3-CpG: 86/Downstream/101939

Nearby gene

ZNF385D(-518737) ; UBE2E2(+933231) ;

Upstream sequence

CCCAAGAATAGTCAAGAACTATTCTGTTCTTGCAGAAAGCTGCTTTTAAACATAGTCCAGAGAACTTGATTTAATCTTATCAATGGCTACCAAAAAGGTT

Downstream sequence

gactctgtagcaagctgctgatccatgagccctactttagggaccaaggGTGTAGAGAACATTTAATTCTTATTTCCTGCCTAATATTATTCTGATTTAT