Basic Information
VIS ID
TVIS10013914
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2159
Orient
+
Integrated sequence
CTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGT| |CAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTG
Host Sequence
Chromosome
chr3
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
29126451/29084960 (Hg38)
End
29126451/29084960 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/3420021; hsa-let-7g/Downstream/2076744;
Nearest TSS
ENST00000440867/Upstream/219736; ENST00000471426/Downstream/195944;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/508481, chr3-CpG: 88/Downstream/1521535
Nearby gene
LINC00693(-326623) ; RBMS3(+196352) ;
Nearest cancer related gene
RBMS3(TSG, +196352) ;
Upstream sequence
GTAgaatttagagctataggttccaatcctgatgttgccactgctagctacgtaactttggacaaattaatctctctttgcctccatttcactctctgta
Downstream sequence
ggatctgtcattggttgcatttaggttgattctatttctttgctattgtgaatagtgctgtaatgaacattcttgggcatgtgtctttattttagaatga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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