Basic Information
VIS ID
TVIS10013915
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
38723926/38682435 (Hg38)
End
38723926/38682435 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/712955; hsa-let-7g/Downstream/455771;
Nearest TSS
ENST00000440867/Upstream/32762; ENST00000432250/Downstream/111575;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/32413, chr3-CpG: 57/Downstream/369543
Nearby gene
SCN5A(-32762) ; SCN10A(+14911) ;
Upstream sequence
ttgtcaaggttactaatgacctccacaatacagagctagttcataaccacacagatctccatgtgccaccttttatagtcacatccagccccctcccacc
Downstream sequence
GGGTAGGGGGTCAATGGGACTTAGTGACTTAACATAAAAGAGGAGGGCAAAATGGAGCCATGGCTGGCCAACTCTGTGTGAACTGCAAGGCAACCCTAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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