Basic Information
VIS ID
TVIS10013917
Fusion event
HBV-LOC105377110 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
59106881/59121155 (Hg38)
End
59106881/59121155 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
LOC105377110
Nearest miRNA
hsa-let-7g/Upstream/3268561; hsa-mir-12124/Downstream/1496650;
Nearest TSS
ENST00000440867/Upstream/56005; ENST00000475527/Downstream/267549;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/70937, chr3-CpG: 48/Downstream/2129777
Nearby gene
C3orf67(-71166) ; FHIT(+628155) ;
Upstream sequence
tctcttgtaggcgtttagtgctataaatttccctctacacactgctttgaatgcgtcccagagattctggtatgtggtgtctttgttctcgttggtttca
Downstream sequence
GAAATATAATTAACTTCATTAAATGCTTAGtaggtgcttttcatgtgtccatctaatccactcaacaatcatatgaggaagataattctcttcttaccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate