Basic Information
VIS ID
TVIS10013919
Fusion event
HBV-LOC110120806 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
-
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
111669452/110748296 (Hg38)
End
111669452/110748296 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC110120806
Nearest miRNA
hsa-mir-12113/Upstream/1259501; hsa-mir-1243/Downstream/112286;
Nearest TSS
ENST00000502981/Upstream/106173; ENST00000512794/Downstream/46107;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/108644, chr4-CpG: 120/Downstream/1397018
Nearby gene
PITX2(-106173) ; FAM241A(+1397101) ;
Upstream sequence
ggcatcaggccagtgcccctctgagacgaagtttccagaggaaggagcaggcagcaatctttgctgttctgtatcctccactggtgataaccaggcgaac
Downstream sequence
CCTTAAACTCTTTCAACATTAATATTGCCTGTAAGGAATCCAGCCATGACCTAAGCCATGGAGCTTTCTGAACCTAGCAAGTAGAAGGGTAAACAGTAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate