Basic Information
VIS ID
TVIS10013923
Fusion event
HBV-PRMT9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2263
Orient
+
Integrated sequence
TATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGT| |CTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAG
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
148596901/147675750 (Hg38)
End
148596901/147675750 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRMT9
Nearest miRNA
hsa-mir-12113/Upstream/331033; hsa-mir-1305/Downstream/106845;
Nearest TSS
ENST00000502981/Upstream/14432; ENST00000510379/Downstream/8375;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/58183, chr4-CpG: 62/Downstream/8053
Upstream sequence
TTAGAATTTTTTTCTATAAGTTCAGAAATTGTATATTAAAACATCTGAATTTCATGCTTTTCTTTTGACCTCAGAACATAGTTGTCTTTGGTTATTCTTT
Downstream sequence
AGAATGCCAGAATGCCCTTTTTCTTTTAACTAGGAAAAACATTATCTTCTTGATTAGCAATTTAAATACATTTTGTTTAAATCTGATGCTACTGGACTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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