Basic Information
VIS ID
TVIS10013927
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2418
Orient
+
Integrated sequence
CCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGT| |CGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTT
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18141838/18140215 (Hg38)
End
18141838/18140215 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/4512258; hsa-mir-12115/Downstream/2388060;
Nearest TSS
ENST00000502981/Upstream/118339; ENST00000511431/Downstream/349293;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/117565, chr4-CpG: 284/Downstream/2111438
Nearby gene
LCORL(-118355) ;
Upstream sequence
gttagggttagggttagggttagggttaagggttagggttagggttagggttagggttagggttagggttagggtggttagggttagggttagggttagg
Downstream sequence
ttgcactctcttcttcagctgggctgtccatatttatctgccctttgacactggtgctcctggttctgaaactggactaagactaggccttataccactg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate