VISDB Viral Integration Site DataBase

VIS ID

TVIS10013931

Fusion event

HBV-APBB2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1814

Orient

-

Integrated sequence

GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC

Chromosome

chr4

Cytoband

p14

Reference genome

Start

End

41075204/41073187 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-424-5p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-3663-3p ; hsa-mir-4638-3p ; hsa-mir-3690 ; hsa-mir-942-3p

Nearest miRNA

hsa-mir-12113/Upstream/571068; hsa-mir-1243/Downstream/6579482;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/215897, chr4-CpG: 95/Downstream/140667

Upstream sequence

gttccccctttgctcttctctctactgctgccttgtgaagaaggtgcctgcttcccctttgccttccgccatgattgtaagtttcctgtggcctccccag

Downstream sequence

TAAAAAATATTTTTTACTTCACTGCTCATATAGCAAGAACAACTACTCCTGAATTTTCAGAGTAAAAAAAACCTAGAATGTAAAAATTCCCCATTATGAT