Basic Information
VIS ID
TVIS10013934
Fusion event
HBV-LINC01170 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1836
Orient
+
Integrated sequence
AGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGC| |CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
123713834/124378141 (Hg38)
End
123713834/124378141 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01170
Nearest miRNA
hsa-mir-10397/Upstream/5223425; hsa-mir-103a-1/Downstream/4719547;
Nearest TSS
ENST00000502646/Upstream/789716; ENST00000510004/Downstream/16898;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/741827, chr5-CpG: 48/Downstream/273564
Nearby gene
CSNK1G3(-761096) ; ZNF608(+258776) ;
Upstream sequence
tcatccatgagcatggggagtgtttcaatttgtttgtgtcatctaagattttttcagtagtgttttgtaattttccttgtagaggtctttcatgtccttg
Downstream sequence
TGCTAAATTACCTTAGGGTTTTAAGAGTCCTTTTAAAAAAAACATGGCAATACATACACAGTATTTTAAAAATCAAATATATAGAAATGGGTTTTTTGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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