Basic Information
VIS ID
TVIS10013935
Fusion event
HBV-LINC01411 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2297
Orient
+
Integrated sequence
AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA| |TAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGA
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
173775676/174348673 (Hg38)
End
173775676/174348673 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LINC01411
Nearest miRNA
hsa-mir-10397/Upstream/1001137; hsa-mir-1229/Downstream/403061;
Nearest TSS
ENST00000502646/Upstream/12178; ENST00000511707/Downstream/155010;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/36142, chr5-CpG: 35/Downstream/372473
Nearby gene
NSG2(-239494) ; MSX2(+375899) ;
Upstream sequence
TATTCAGTTCTGCATAAGTTTTGTGGAACAAGTTTTCTTTTAAACTGGGGTTGACAAACTTCCGTACATGGGccaaatccagccatctgtgtttttctgt
Downstream sequence
TGTCATGAAGAGGAAAGGAAAAATAAAGAAACCTTTAACAATTTGCCATATTGTATGCTTTGGAAGAGCCTAGTAAACTTGCCAGCAAATTGCTTCTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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