Basic Information
VIS ID
TVIS10013936
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
24767190/24767081 (Hg38)
End
24767190/24767081 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/7611089; hsa-mir-103a-1/Downstream/7169021;
Nearest TSS
ENST00000502646/Upstream/122103; ENST00000642022/Downstream/73502;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3307338, chr5-CpG: 68/Downstream/423313
Nearby gene
CDH10(-122105) ; LINC02239(+68199) ;
Upstream sequence
TCCATTTCTGCTTTTATGAAATCTGCTTCTTTATTGCTTCTTTATGAAGCAATTACCTGCAAAATGCTTTTTCTGGTTTGGTGCTGGAAAACCAACCAAA
Downstream sequence
GGGCGGTTTATGTAACAGTTTCAGTAAAAAATAAATGAAACAGTAACAGTATTGTGCCCAAAGGGACATACTGTTACATGCATGTTACATTTCCCCAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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