Basic Information
VIS ID
TVIS10013938
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1650
Orient
-
Integrated sequence
CCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGT| |CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
52980534/53684704 (Hg38)
End
52980534/53684704 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/15127143; hsa-mir-103a-1/Downstream/266800;
Nearest TSS
ENST00000502646/Upstream/38509; ENST00000512618/Downstream/134972;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/123664, chr5-CpG: 59/Downstream/625398
Nearby gene
NDUFS4(-1363) ; ARL15(+200080) ;
Upstream sequence
AACTTTTCATAGGCAGATACCGTAACTCAAAATGTTTTTTTAATCTGGTTGGTAATGTCCTCTGGGCTTTAGAGTATCTATTTTCCCTTAATCATTTCAG
Downstream sequence
TTCCATTTAATTTGAAAAATGCACTTACAGGCAAATAGCCTGTAGATATACAGAGGTAAatgtccaaagatgtttattgtaaagttgttgctagtagcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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