VISDB Viral Integration Site DataBase

VIS ID

TVIS10013941

Fusion event

HBV-PTPRK integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1805

Orient

+

Integrated sequence

TACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCG| |CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG

Chromosome

chr6

Cytoband

q22.33

Reference genome

Start

End

128629062/128307917 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-133b ; hsa-mir-9-5p ; hsa-mir-935 ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-218-5p ; hsa-mir-1283 ; hsa-mir-7849-3p ; hsa-mir-548c-3p

Nearest miRNA

hsa-mir-10398/Upstream/1823204; hsa-mir-1202/Downstream/3484255;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/791356, chr6-CpG: 173/Downstream/211096

Nearest cancer related gene

PTPRK(TSG, No orient, 0)

Upstream sequence

GAGAATGTATATATCCTAAAAAAAGGTTTCTTGCCTCTTGCCATCCCACCCTGTAATTTGTGACATCCCAAATAACCTTCTCATGCTTCAGATTCACCAT

Downstream sequence

catgacttagcaatatcactacttagcaatatcatacacatgtacatgaatgctcataacaacatttttaaaaatattaccactagaaaaccagaaaaca