VISDB Viral Integration Site DataBase

VIS ID

TVIS10013946

Fusion event

HBV-CDKAL1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

637

Orient

+

Integrated sequence

GCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAAT| |TCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGT

Chromosome

chr6

Cytoband

p22.3

Reference genome

Start

End

20560295/20560064 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-let-7e-5p ; hsa-mir-1273e ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1282 ; hsa-mir-5707 ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-890 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6089 ; hsa-mir-6499-5p ; hsa-mir-5693 ; hsa-mir-500a-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-3162-5p ; hsa-mir-4266 ; hsa-mir-7154-3p ; hsa-mir-1288-3p ; hsa-mir-202-3p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-7162-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-3169 ; hsa-mir-6840-3p ; hsa-mir-4459

Nearest miRNA

hsa-mir-3691/Upstream/1988184; hsa-mir-10398/Downstream/6587562;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/156512, chr6-CpG: 131/Downstream/1027126

Upstream sequence

ATCATATGCCTCTTATAAAATACCACCCTCCGAGGCTGTGGAGAAAAGTTCTTTATCCCCGCTCTCCACCCCATTTCCTGCAACTTCTGTGAAGTCACAG

Downstream sequence

GTCATGTGTTTGGATTAAAGACATGATGTATTTTTAGCTATTGGGCAAGAGATGGCAATATTGCATTACATGATCACTGCAGTTACACTATTATAAATGA