VISDB Viral Integration Site DataBase

VIS ID

TVIS10013947

Fusion event

HBV-CDKAL1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1863

Orient

+

Integrated sequence

AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACT| |GTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTT

Chromosome

chr6

Cytoband

p22.3

Reference genome

Start

End

20568400/20568169 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-let-7e-5p ; hsa-mir-1273e ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1282 ; hsa-mir-5707 ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-890 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6089 ; hsa-mir-6499-5p ; hsa-mir-5693 ; hsa-mir-500a-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-3162-5p ; hsa-mir-4266 ; hsa-mir-7154-3p ; hsa-mir-1288-3p ; hsa-mir-202-3p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-7162-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-3169 ; hsa-mir-6840-3p ; hsa-mir-4459

Nearest miRNA

hsa-mir-3691/Upstream/1996289; hsa-mir-10398/Downstream/6579457;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/164617, chr6-CpG: 131/Downstream/1019021

Upstream sequence

attgtgatgttagggtgtcaattttggatctttcctgctttctcttgtaggcatttagtgctataaatttccctctacacactgctttgaatgcgtccca

Downstream sequence

cccagcacccagctaatttttaaattttttgtagagacggagtcttgccattttgcccaggctctcctccaactcctggcctcaagggatcctcccactt