Basic Information
VIS ID
TVIS10013953
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr7
Cytoband
q31.32
Reference genome
GRCh37/hg19
Start
122645244/123005190 (Hg38)
End
122645244/123005190 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/5984871; hsa-mir-10399/Downstream/4052898;
Nearest TSS
ENST00000635602/Upstream/9490; ENST00000419832/Downstream/98399;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/118285, chr7-CpG: 43/Downstream/527488
Nearby gene
TAS2R16(-9490) ; SLC13A1(+108344) ;
Upstream sequence
GTGACTCTGTGTATGCTTTTTATATTTATAACTCAAACTAGAGTTTAGCAAGCTCACTTGTtatagattcatataggatatatacatagatatgctttta
Downstream sequence
TTCCACCAAATATAAAAGAAGTGAGGTGtttttcattttttaattatttctattttttttgaaggcgtctggctctgttgcccaggctggaatgctgtca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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