Basic Information
VIS ID
TVIS10013957
Fusion event
HBV-CCT6P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1784
Orient
+
Integrated sequence
TCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCT| |GTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGC
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
64521754/65061376 (Hg38)
End
64521754/65061376 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA7J
Target gene
CCT6P3
Nearest miRNA
hsa-mir-1183/Upstream/382200; hsa-mir-10399/Downstream/2052946;
Nearest TSS
ENST00000635602/Upstream/54633; ENST00000632111/Downstream/207998;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/22325, chr7-CpG: 36/Downstream/13498
Upstream sequence
TGACTTTGggagaatagatagtaggagaagagaaagatttgggtatttattccccctactcgctcagccaaactatgtttcctttaccttatgaccacag
Downstream sequence
aaataataataaaaataataataataGAAGTACATACATAAATTTTAAAGTGTAGTAGAAATTATATTTTGTATTCACCCTTTTCCCCTCTGTGAATGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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