Basic Information
VIS ID
TVIS10013966
Fusion event
HBV-CPQ integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2113
Orient
+
Integrated sequence
TATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCT| |GGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCA
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97775449/96763221 (Hg38)
End
97775449/96763221 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
CPQ
Nearest miRNA
hsa-mir-12123/Upstream/1690225; hsa-mir-10400/Downstream/1630424;
Nearest TSS
ENST00000518652/Upstream/1981; ENST00000532528/Downstream/266248;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/117506, chr8-CpG: 100/Downstream/514155
Upstream sequence
TGTGTAAACATATGTGTTGGACATAAATGCACTAAAATTAAAGTTAAATCCAATTTCTAAAAACTTACAAAAACTAAATTATGCCAGTTCCCCAATCTGC
Downstream sequence
ctggaagtcaggactttaacatatgaatttggggggtacataactgagcttataattcatggatgaaagtgtttttttcccatatggatattcaattgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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