Basic Information
VIS ID
TVIS10013968
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2431
Orient
+
Integrated sequence
CCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTC| |AATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGA
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
121476999/118714721 (Hg38)
End
121476999/118714721 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02578 ; LOC102724929
Nearest miRNA
hsa-let-7a-1/Upstream/4505192; hsa-mir-12126/Downstream/1530258;
Nearest TSS
ENST00000422679/Upstream/8761; ENST00000456032/Downstream/25842;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/969357, chr9-CpG: 97/Downstream/654087
Nearby gene
TLR4(-997230) ; BRINP1(+451909) ;
Upstream sequence
atgttgtgtccttgttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcaggttgttcagttt
Downstream sequence
cctcccaaagtgctgggattaaaggcatgagccactgtccctggccCTGtaggggaaaatgttatttaaagacaaagatgtacatcttagatgtgttcat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate