Basic Information
VIS ID
TVIS10013969
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
121477011/118714733 (Hg38)
End
121477011/118714733 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02578 ; LOC102724929
Nearest miRNA
hsa-let-7a-1/Upstream/4505204; hsa-mir-12126/Downstream/1530246;
Nearest TSS
ENST00000422679/Upstream/8773; ENST00000456032/Downstream/25830;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/969369, chr9-CpG: 97/Downstream/654075
Nearby gene
TLR4(-997242) ; BRINP1(+451897) ;
Upstream sequence
AATCAACCATAGTCCCTGGTACTAGACAGGGAGCAGTGTCTGATGGAGCCAAATTCCAAATGTGGTTGATTGTTCAGAAGTGACAATTCTGCCAGAGATG
Downstream sequence
ctgggattaaaggcatgagccactgtccctggccCTGtaggggaaaatgttatttaaagacaaagatgtacatcttagatgtgttcattgctataaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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