Basic Information
VIS ID
TVIS10013971
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
98548930/95786648 (Hg38)
End
98548930/95786648 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/700554; hsa-mir-12126/Downstream/1576906;
Nearest TSS
ENST00000422679/Upstream/14325; ENST00000426805/Downstream/88422;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1902, chr9-CpG: 100/Downstream/88315
Nearby gene
PTCH1(-269683) ; LINC00476(+19440) ;
Nearest cancer related gene
PTCH1(TSG, -269683) ;
Upstream sequence
ccagcctcactgtcatttctaataagtctgtctcgttgctttgcttttgagatcttctctttgtcttggtcctctgtagtttcagtctgatatgtttagg
Downstream sequence
aagagggcacctgggtctgtggaaatggggaaggggtggcggtgaccttgtgaccgagggcagaagcctcaggctgggaggtgccctgggattctggttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate