Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013972
Fusion event
HBV-MAOB integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|Polymerase|
Start
1606
Orient
+
Integrated sequence
CGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGT| |CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
Start
End
43681691/43822444 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-628-5p ; hsa-mir-671-5p ; hsa-mir-4786-3p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-335-5p ; hsa-mir-124-5p ; hsa-mir-1290 ; hsa-mir-2114-5p ; hsa-mir-3153 ; hsa-mir-3167 ; hsa-mir-361-3p ; hsa-mir-4668-5p ; hsa-mir-5004-3p ; hsa-mir-5010-3p ; hsa-mir-554 ; hsa-mir-5588-3p ; hsa-mir-6124 ; hsa-mir-6134 ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-876-5p
Nearest miRNA
hsa-mir-1587/Upstream/3984831; hsa-let-7f-2/Downstream/1923713;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/166011, chrX-CpG: 49/Downstream/59609
Upstream sequence
tgtgtcccagagattctggtatgttgtgtctttgttctcgttggtttgaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattc
Downstream sequence
AAGATTCTGATTAGAAGAATATTCTGAAGACTAGTCGAGAGATGACACAGCAGGAGAAACCTGGAGTGAGATTCAGATGAAGGAAGAGGCAAGTTTGGCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.