VISDB Viral Integration Site DataBase

VIS ID

TVIS10013973

Fusion event

HBV-DIAPH2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1943

Orient

+

Integrated sequence

TCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGA| |GTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCAT

Chromosome

chrX

Cytoband

q21.33

Reference genome

Start

End

96072009/96817010 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p

Nearest miRNA

hsa-let-7f-2/Upstream/1753784; hsa-mir-105-1/Downstream/9822804;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/131643, chrX-CpG: 23/Downstream/3122326

Upstream sequence

gacgcagaggttgcagtgagctgagatcaagccactgcactccctccagcctgggcagcagagcaagacaccacctcaaaaaaaaaaaaaaGCCATTAAC

Downstream sequence

gagctaaaaaatcaaagcatttggactcaaggatatggagaatagaatgatgattatcagtggctgggaagcgtagtgatggggaagtggggatggttaa