Basic Information
VIS ID
TVIS10013978
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1843
Orient
+
Integrated sequence
GGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCA| |TCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGA
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21798515/21798516 (Hg38)
End
21798515/21798516 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/286331; hsa-let-7a-1/Downstream/7065110;
Nearest TSS
ENST00000422679/Upstream/316203; ENST00000580675/Downstream/4027;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/101761, chr9-CpG: 68/Downstream/3606
Nearby gene
MIR31HG(-238818) ; MTAP(+4120) ;
Nearest cancer related gene
MTAP(TSG, +4120) ;
Upstream sequence
cttgagctgacaaacttgtcagacttattagcttgtcactgtttttgtcctgggtcttgtagctgatgaagtgactgcaatagaaaccccagtgttaatt
Downstream sequence
ATTTGAAGTGAACTTTGAAGACAAGACAAGGTGATTTGCAATGAAGGATATTTCTAGGGTAAAAGGGACTTTGAATAGAAGGAACGAATAAAGAAAACTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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