Basic Information
VIS ID
TVIS10013979
Fusion event
HBV-CDKN2B-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
22047158/22047159 (Hg38)
End
22047158/22047159 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA9C
Target gene
CDKN2B-AS1
Nearest miRNA
hsa-mir-101-2/Upstream/534974; hsa-let-7a-1/Downstream/6816467;
Nearest TSS
ENST00000422679/Upstream/408; ENST00000645223/Downstream/64912;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/37687, chr9-CpG: 21/Downstream/107319
Upstream sequence
ttgtttggataaaaaggctacagggcgcggtcccggttcttgtgtaagaattctgactgcacagccctgcactccagctgtgggtaatgaaaagggttgg
Downstream sequence
tgctcttctcacctcctttcccttcctttttcttttctcctcttTATTTTGTCTGTACCCAATAGCTTTTCCCAAGCCTTAAAACTATGTATAGGTATAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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