Basic Information
VIS ID
TVIS10013981
Fusion event
HBV-PDCD6IPP2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
375
Orient
+
Integrated sequence
TTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGC| |TGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTT
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
29060458/28815312 (Hg38)
End
29060458/28815312 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
PDCD6IPP2
Nearest miRNA
hsa-mir-1268a/Upstream/324467; hsa-mir-10393/Downstream/2249720;
Nearest TSS
ENST00000557528/Upstream/76881; ENST00000559709/Downstream/33363;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/25748, chr15-CpG: 50/Downstream/16793
Upstream sequence
CCTGATGTTCAATTTATATTTGGCTCTCTGAGAACTCATCTCTCTCTCAGCCCAAATGAACCTTTATATATTATTTCCTTCTTGAAATTGGCTTTTTTTT
Downstream sequence
TCAGTTAAACTAAAGTGTCTTTTTTATTGTTTAGGTTGTAAATGTCTTAAAATCCTTATTGTCAAATCTTGATGAAGTAAAGAAGGAAAGAGAGGGTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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