Basic Information
VIS ID
TVIS10013986
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2034
Orient
+
Integrated sequence
TACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCT| |CCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAG
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121484064/121742266 (Hg38)
End
121484064/121742266 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4647538; hsa-mir-1182/Downstream/24108321;
Nearest TSS
ENST00000473358/Upstream/161742; ENST00000443018/Downstream/21758246;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/222539, chr1-CpG: 312/Downstream/3343243
Nearby gene
EMBP1(-170378) ;
Upstream sequence
tcaaaactgctctatgaaaagcaatgttatcctctgggagttgaacacaagcctcacaaaggagtttttgagaatgcttctgtttactttttatgctaga
Downstream sequence
cagaagaattctcagtaacttccttgtgttgtgtgtattcaactcacagagttgaacgatcctttacacagagcagacttgaaacactctttttctggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate